Bioprocessing scale-up and production is rapidly evolving in an ongoing effort to improve product yield, consistency, and quality. Innovations in new expression systems bring new challenges in process aeration and filtration. Mott’s bioprocessing filters are specifically designed for high-cell-density broth filtration, improves yields and accelerates filtration efforts, addressing critical challenges in bioprocessing. Our bioprocessing filter solutions are tailored to meet the unique requirements of each bioprocessing application, ensuring optimal performance in separating cells and other particulates from the culture medium. Talk to one of our application engineers to learn more about how Mott filtration systems, including our advanced bioprocessing filter options, can solve your challenges in bioprocessing and enhance your production efficiency.
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Literature & Data Sheets
- Tangential Flow Filtration
- Cell Retention Systems
- Cell & Debris Separation
- Cell Harvest
LSI Filters from Mott incorporate inside-out filtration for better backwashing and reliability.
A comprehensive overview of Mott's offerings for process filtration applications.
Our systems are designed using a graded design approach. This approach includes filter feasibility testing, pilot testing, engineering design, filter system fabrication, and operational support.
Computational Fluid Dynamics (CFD) modeling is an excellent service to accelerate product development. It allows for cost-effective equipment sizing and identification of optimal operational parameters.
Porous metal media is made to last a lifetime. This cleaning guide provides proper care and cleaning instructions to ensure longevity and reliability.
Filter feasibility testing and application analysis for liquid and gas filtration processes.
Common Diameters – 4” to 72” diameter vessels are common to accommodate a wide range of flow rates.
Custom vessels are available upon request, consult factory
Media grade elements down to 0.2 um are available to capture even the smallest particles in your process for a purer end product.
Common filter element alloys – 316L SS, 310 SS, Hastelloy C-276, Hastelloy X, Monel 400, Nickel 200, Inconel 600
Common vessel alloys – 316L SS, Inconel, Hastelloy
Other alloys are available, consult factory
Alloys with temperature resistance up to 1400 degrees Fahrenheit are available.
Custom alloys available to accommodate unique operating temperatures, consult factory
Mott’s bioprocessing filter is designed for clean-in-place performance, meaning filter elements can discharge cake build-up without having to open the filter for maintenance. Once a terminal pressure drop has been reached, the cleaning cycle automatically initiates to discharge cake build-up through gas assisted pulse or through a backwash cycle.
Particles will embed in the filter media over time, requiring the elements to be cleaned by a third-party company. Various cleaning techniques can be used to prolong life of the elements. For a recommendation of a cleaning company, please contact a Mott representative. It is recommended you keep a spare set of filter elements to continue operations while elements are being cleaned.
Videos & Articles
The Mott Filter Design Process
- Filter Feasibility Testing – In our Customer Innovation Center, we will replicate, or very closely correlate, your process conditions to determine the appropriate media grade and material for your bioprocessing filters application. We will provide you with a comprehensive, in-depth analysis to prove the feasibility of using porous metal bioprocessing filters in your process and furnish you with a comprehensive ROI justification.
- Pilot Testing – As an option, we can install a pilot unit in your facility enabling you to witness, first-hand, how our bioprocessing filters will perform in your process stream and under your actual operating temperatures and pressure conditions.
- Front-End Engineering Design – Our Front-End Engineering Design (FEED) process provides you with a complete process engineering package for bioprocessing filters, including vessel drawings, a preliminary equipment layout drawing, piping and instrumentation diagram, process flow diagram, valve and instrument list, and a detailed process functional description.
- Fabrication – When it comes to fabricating your system, we can handle as much or as little as you need – from fabricating only the filter vessel for bioprocessing filters, to providing a complete turnkey skid system.
- Operational Support – When your filtration system is complete, our professionals can provide equipment commissioning and startup services, training, ongoing technical support, and quality assurance testing for the life of your bioprocessing filters system.
Depending on your needs, Mott can provide just the filter elements, a vessel and elements, or provide you a full turnkey system with the vessel, frame, piping, instruments, and controls for bioprocessing filters.
Filter Feasibility Testing – Want a recommendation on the correct filter media, alloy, and backwash frequency for your bioprocessing filters? Coordinate with a Mott representative to send a sample of your feedstock to our lab to determine the correct filtration design for your process.
Preventative Maintenance Cycles – Consult with a Mott representative about utilizing a pre-determined lab testing and cleaning schedule for your bioprocessing filters to avoid costly downtime.
Engineering Support – Utilize our expert project engineers to design the right bioprocessing filter to maximize flow and particle capture.
Destructive Element Analysis – Send us one of your bioprocessing filter elements for various analyses to determine the remaining lifetime and filtration efficiency of your filters.
Advanced Bioprocessing Filter Solutions by Mott
Mott’s bioprocessing filter technology is at the forefront of enhancing efficiency and reliability in the biopharmaceutical industry. These bioprocessing filters are specifically designed to meet the rigorous demands of bioprocessing applications, including cell culture, fermentation, and harvest processes. Utilizing state-of-the-art porous metal media, Mott’s bioprocessing filter solutions offer exceptional durability and performance in high-temperature and corrosive environments, ensuring optimal product yield and quality. Tailored to support scalable operations, these filters provide a critical component for any bioprocessing workflow, from pilot to full-scale production, enhancing separation efficiency and process control.
FAQs: Bioprocessing Filter
Q: What is a bioprocessing filter?
A: A bioprocessing filter is a specialized filtration device designed for use in the biopharmaceutical industry to separate and purify biological materials, such as cells, proteins, and nucleic acids, during the bioprocessing stages. These filters are engineered to meet the stringent standards of purity, efficiency, and reliability required in biomanufacturing processes.
Q: How do bioprocessing filters improve production efficiency?
A: Bioprocessing filters improve production efficiency by enabling the effective separation of desired biological components from culture media or process streams. This results in higher product yields, reduced process times, and lower costs by minimizing the need for further purification steps. Their design also supports consistent performance under a range of process conditions, including high pressures and temperatures.
Q: Can bioprocessing filters be used for all types of bioprocesses?
A: Yes, bioprocessing filters are versatile and can be used in a variety of bioprocesses, including fermentation, cell culture, and downstream processing. They are suitable for a wide range of applications, from small-scale laboratory research to large-scale commercial production, and can be customized to meet the specific requirements of different biological materials and process conditions.
Q: Are bioprocessing filters compatible with high-temperature processes?
A: Bioprocessing filters are designed using materials that can withstand high temperatures, making them compatible with processes that require sterilization or involve high-temperature operations. The specific temperature range and compatibility depend on the materials used in the filter construction, so it’s important to select a filter that matches the process requirements.
Q: How are bioprocessing filters maintained?
A: Maintenance of bioprocessing filters typically involves regular cleaning and sterilization to prevent clogging and maintain filter integrity. Many bioprocessing filters are designed for single-use to eliminate cross-contamination risks, while reusable filters can often be autoclaved or cleaned with appropriate solutions. The specific maintenance procedures depend on the filter design and the manufacturer’s recommendations.
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