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Drug Delivery Implantables

Pharmaceutical and medical device companies are constantly exploring new ways to deliver drug molecules to patients. An exciting frontier in drug delivery technology is in the field of implantable drug delivery devices.

Surgically implanted devices already serve a wide variety of functions in modern medicine, from titanium replacements for failed joints to electronic devices that help the human heart maintain its rhythm. Using medical implants in the administration of drugs offers doctors and researchers the ability to monitor and control dosages more closely than ever before. In addition to this, they are able to more effectively localize drug deployment to a specific area of the body. Both of these innovations can lead to improved patient outcomes and better data.

Through passive diffusion, we can control drug flow rates to achieve a therapeutic dosing window for six months or more using an implantable package. Our solutions are ideal for drugs that require frequent injection or dosage or can cause elevated plasma toxicity levels. They also offer manufacturers new drug delivery options to provide a competitive advantage in the marketplace. Mott can also conduct drug diffusion feasibility studies to help guide the design criteria for your next-generation, controlled-release drug delivery product.

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Developing and deploying new implantable drug delivery technologies requires the highest-quality drug delivery flow elements. These are essential for building safe, effective, medical-grade pharmaceutical drug delivery devices. Mott can supply filtration and flow control components built to the most exacting standards for controlled release drug diffusion and other sensitive implantable applications

Whether you are just beginning to explore the feasibility of drug delivery flow elements and implant-based disbursement for a new drug product or your project is already well into the design phase, bringing our experienced team on board can help overcome any design obstacles. Additionally, we ensure the viability of your product, analyze your processes, and collect the data you need to move forward with production or make changes so your pharmaceutical drug delivery devices are successful.

Controlled Release Testing with Proven Membrane Technology by Mott

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Call us at 860.747.6333, or submit an information request form and someone will get back to you within 48 hours.

Literature & Data Sheets

Typical Applications

  • Low-Flow Drug Delivery. Implant-based drug disbursement allows for extremely low-flow drug delivery whereby low doses can be released into a patient’s bloodstream on a tightly controlled timeline.
  • Implantable Sustained Release. Medical implants can release a slow, steady dose of medication more consistently than extended-release oral pills. This allows doctors to better control drug diffusion throughout a patient’s body.
  • Catheter-Based Release. Recent studies have shown promise in using catheter-based treatments to deliver cells directly to the heart, for example.
  • Overdose Protection. Using implants to tightly control the release of medication into the bloodstream makes overdose extremely unlikely.

Low-Flow Drug Delivery

Mott can customize delivery devices to meet specific requirements to manage extremely low flows for the release of therapeutic agents to optimize patient outcomes.

Implantable Controlled-Release Drug Delivery Testing

Let Mott conduct your initial drug diffusion feasibility studies to guide the design criteria for your next-generation controlled-release drug delivery technology.

Lab and Engineering Services

Dealing with a complex, critical application? Rely on our engineers and scientists to solve your challenge.

Controlled-Release Drug Diffusion Tech Brief

Mott's controlled-release drug diffusion studies reduce in vitro test time by more than 90%.

Product Specs

Drug Flow Rates

We can customize passive diffusion membranes in a range of porosities and dimensions to meet drug delivery flow rate requirements and concentration over time. Therapeutic window can be maintained consistently for extended periods.

Flow Accuracy

Achieve consistent zero-order drug release for extended periods at tight dose standard deviation.

Device Hardware

Assemble your flow element into an array of hardware options.

Materials

We employ biocompatible titanium and 316L stainless steel, which have been successfully proven for use in implanted devices. As always, custom alloys and materials are available upon request.

Our Design Capabilities

  • Customizable, ultra-small components used in implantable devices
  • Integrated device concept manufacturing for proof-of-concept trials or transition to production
  • Extensive partner network for new materials

Relevant Services

Your relationship with Mott doesn’t end with purchasing our state-of-the-art implantable drug delivery technology. We use data, comprehensive testing, and advanced modeling techniques to empower every one of our partners to use their Mott drug delivery flow elements in the most effective and efficient ways. Our well-earned reputation rests on the success of our partners. That’s why we offer the following services and more to validate and maximize the effectiveness of your Mott implantable drug diffusion technology:

  • Drug Diffusion Testing: If you need data packages or flow feasibility testing for your molecule or device concept, we’d welcome the opportunity to work with you.
  • Computational Fluid Dynamics: If you would like to model your process fluids interaction with your Mott-requested part, ask your Mott representative how we can model it using CFD software.
  • Additive Manufacturing: Controlled porosity 3D printing makes it possible to integrate hardware and drug flow elements using a single print. Your custom parts can be printed with a variety of densities, thicknesses, and porosities. If your project is stalled due to a need for a part in a non-traditional shape or size, Mott’s additive manufacturing solutions are your missing link!
  • Application Engineering and Customer Innovation Center: Bring Mott onboard to help with your project. Our experienced engineers and professionals are here to provide support as you build your new medical technology from the ground up. We’ve worked with some of the industry’s most high-profile brands, and we’re excited to take on your next project. Our Customer Innovation Center, located in Connecticut, is a state-of-the-art design and testing facility dedicated to helping our clients bring their boldest visions to market. At Mott, we aim to be more than merely a design and consulting firm – we’re your partners in changing the world.
  • Rapid Prototyping: When you need to proof your design as rapidly as possible, turn to the experts and engineers at Mott’s Rapid Prototyping Cell. We use the highest quality manufacturing equipment and most stringent quality control processes to fast-track your development timeline without sacrificing quality.
  • Lab Testing: Mott’s fully featured testing lab is staffed by the top scientists and industry experts who take pride in adding value to every one of our clients’ projects. Testing drug diffusion technologies and validating custom drug delivery flow elements require rigorous testing and extremely precise measurements to ensure safety and efficacy. Mott’s lab is the perfect proving ground for the pre-trial stages of developing and testing your implantable drug delivery technology.