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Aug 2018

LC/MS Scientists are Putting Down their Scissors and Picking Up the Latest in Method Development Technology

Discovering and selecting the next blockbuster drug to treat human disease is a monumental task. With thousands of molecules vying to move through the pipeline or frequent requests from the bioprocess manufacturing teams, analytical scientists need to maximize use of their time to enable accurate information to be collected and conveyed to stakeholders. Molecules aren’t getting any easier to analyze, so having the right tools available is critical to efficiently produce analytical data.

At Mott (the company behind PerfectPeak Chromatography), we often work with large pharmaceutical companies to develop solutions for chronic filtration and flow control issues they're experiencing with LC instruments. We find customers often spending an extraordinary amount of time setting up their instruments instead of spending time on actual analysis. One product we found to be consistently problematic was post-column flow splitters. Between DIY solutions and bulky, difficult-to-install splitters with mounting apparatuses, we figured there simply had to be a better way to split a fluid post-column. 

So Mott developed just that. A post-column flow splitter that utilizes finger tight fittings for quick-installation, eliminating the need for wrenches or scissors. We tested this new product at one of the largest pharmaceutical companies in the world to see the improvements. Here are the results:

The Challenge: Wasted Time Setting Up Flow Splits

LC/MS scientists in the R&D department at this pharmaceutical company, needing to split their sample post-column, were manually cutting PEEK tubing in order to split the sample between the mass spec and waste. This type of approach can lead to poor accuracy, lack of reproducibility and can also create excessive backpressure. More importantly, manually cutting tubing is a waste of valuable time. When highly paid scientists are spending precious minutes and hours setting up an instrument for analysis, pharmaceutical companies are incurring tens-of-thousands of dollars in inefficient labor costs while also slowing down their speed to drug discovery and commercialization.

Simply put, with an average time to market of 12 years for new drugs, time is of the essence. When you’re in the R&D lab of a major pharmaceutical company and people are depending on your analysis and testing for mission-critical data, you shouldn’t have to spend time cutting tubes to make flow splitters for your analytical setup or validate flow accuracy prior to the install.

The Method Setup:

 

The Solution: Quick to Install and Ready to Split

The pharmaceutical company utilized the new, state-of-the-art flow splitter technology developed by Mott Corporation that is easy to install and ready to split flow right out of the box. With a patented design at approximately 5 μL internal volume, the combination of finger-tight design and multi-pore technology enables not only a fast, accurate split, but is small and light-weight to be put anywhere in your setup. They quickly achieved the 0.2 ml/min flow rate to their mass spec by using a Mott 5:1 flow splitter right out of the box.

                                             

                                                          PerfectPeak Flow Splitter from Mott   


                                                 

 

Results: Time Saved and Data Ready

Our customer now saves critical hours in the work week. Instead of cutting PEEK tubing, verifying flow rates and attempting to maintain outdated or homemade splits. Those saved minutes and hours can now be spent designing new experiments, collecting data, reviewing results and providing reports to stakeholders for critical company decisions.

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