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Sep 2018

Mercachem Shows Dramatic Peak Improvement and Better Resolution using PerfectPeak Flow Splitters

Contract Research Organizations (CROs) face some of the most demanding timelines and challenges to develop methods and deliver credible data
when analyzing molecules. Scientists rely on this data in the drug discovery process to help convert leads into viable pipeline options. The dynamics
of establishing the right analytical setup with various column separations, flow rates, and detection methods can make or break an analysis, and
having the right tools available makes all the difference.

THE METHOD SETUP

THE CHALLENGE: FLOW SPLIT INACCURACY AND PEAK DISPERSION

When using her existing splitter technology, Colinda van Tilburg, a group leader of analytical chemistry at Mercachem, experienced difficulty in
getting the required results for a pharmaceutical analysis. Data generated using a generic T-splitter with tubing showed excess dispersion and
variability in peak shape.

THE SOLUTION: BETTER RESOLUTION PEAKS WITH ACCURATE FLOW SPLITTING

Using a Mott PerfectPeak® Flow Splitter, the accurate flow and extremely low dwell volume enabled Colinda to collect data faster with better
peak resolution.

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