Our Latest

Enhancing Chromatography with Bioinert HPLC and 3D Materials

Enhancing Chromatography with Bioinert Materials: Quality, Yield, and Consistency

In the field of chromatography, the use of bioinert materials is revolutionizing the industry, particularly in the development of personalized medicine. This article delves into how bioinert materials improve chromatography processes, ensuring better quality, yield, and consistency. We’ll also explore the role of advanced chromatography materials, the integration of 3D chromatography, and the critical impact on drug development.

The Importance of Bioinert HPLC in Chromatography

What is Bioinert HPLC?

High-performance liquid chromatography (HPLC) is a technique used to separate, identify, and quantify components in a mixture. Bioinert HPLC involves the use of materials that do not interact with biological samples, preventing any interference with the analytical process. This is crucial for obtaining accurate and reliable results in pharmaceutical and biotechnology applications.

Growing Impact of Personalized Medicine

The advent of personalized medicine has transformed how diseases are identified, classified, and treated. This new approach focuses on creating treatments tailored to individual patients based on their genetic and molecular profiles. Personalized medicine promises to deliver more effective therapies with fewer side effects, targeting the right treatment at the right dose at the right time.

Benefits of Personalized Medicine

  • Better Lifestyle Interventions: Personalized medicine enables early detection of diseases and the implementation of lifestyle changes to prevent illness.
  • Active Treatment Monitoring: Continuous monitoring allows for timely adjustments to treatment plans, improving patient outcomes.
  • Faster Clinical Trials: Patients can be matched with clinical trials more quickly, speeding up the development of new therapies.
  • Individualized Treatment Strategies: Tailored treatments ensure that patients receive the most effective therapies for their specific conditions.

The Necessity of Advanced Chromatography Materials

Avoiding Common Pitfalls

As chemistries and workflows become more complex, the need for innovative materials and new instrument designs becomes critical. Here are three key pitfalls to avoid:

  1. Protein Sticking to Metal: Traditional stainless steel can cause proteins to stick, leading to inaccurate results. Bioinert materials like polymers and titanium prevent this problem, ensuring that biological samples remain uncontaminated.
  2. Inconsistent Results: Consistency is paramount in analytical chemistry. Bioinert materials provide accurate, reproducible data, essential for validating assays and ensuring that new drugs work as intended.
  3. Sampling Delays and Costs: Real-time sampling is crucial for identifying issues with yield, quality, and consistency. Bioinert HPLC and advanced chromatography materials reduce delays and lower the cost per sample, enabling quicker adjustments and improvements in the manufacturing process.

Integration of 3D Chromatography

What is 3D Chromatography?

3D chromatography involves the use of three-dimensional printing technology to create custom chromatography materials and components. This innovative approach allows for the precise control of material properties and the creation of complex structures that enhance the performance of chromatography systems.

Benefits of 3D Chromatography

  • Customizable Designs: 3D printing enables the creation of tailored components that meet specific analytical requirements.
  • Improved Efficiency: 3D-printed materials can optimize flow paths and reduce dead volumes, enhancing the efficiency of chromatographic separations.
  • Enhanced Performance: The ability to design and produce intricate structures improves the resolution and sensitivity of chromatography systems.

Mott’s Expertise in Bioinert Materials and Chromatography

Mott Corporation works with the world’s largest pharmaceutical and instrument manufacturers to develop customized solutions that improve results and repeatability. Our state-of-the-art Customer Innovation Center collaborates with clients to create advanced filtration and flow control technologies.

Key Offerings

  • Bioinert HPLC Materials: Mott’s bioinert materials ensure accurate and reliable chromatography results, essential for drug development and personalized medicine.
  • 3D Chromatography Components: Utilizing 3D printing, Mott creates custom chromatography materials that enhance system performance and efficiency.
  • Integrated Assemblies: Mott designs and manufactures integrated assemblies that streamline workflows and improve analytical outcomes.

Contact Us

If you’re working on a project that requires advanced filtration or flow control support, Mott’s team of engineers is eager to assist. Our expertise in bioinert HPLC, chromatography materials, and 3D chromatography can help you achieve superior results. Contact us today to learn more about our capabilities and how we can support your innovative projects.

About the Author

My name is Greg Tedeschi, and I am the Product Manager of Life Sciences at Mott. If you have feedback on this article or would like to discuss how Mott can help with your chromatography needs, feel free to email me or connect on LinkedIn. Our engineering team is ready to collaborate on developing the latest technologies in chromatography.